Directori de persones
Josep Enric Esquerda Colell

Josep Enric Esquerda Colell

Grau: Doctor/a

973 702 427
josep.esquerda(ELIMINAR)@udl.cat

ResearcherID: http://www.researcherid.com/rid/A-7377-2010

Publicacions

  • Hernández, S; Salvany, S; CASANOVAS, A; PIEDRAFITA, L; Soto-Bernardini, MC; Tarabal, O; Blasco, A; Gras, S; Gatius, A; Schwab, MH; Calderó, J; ESQUERDA, JE

    Persistent NRG1 Type III Overexpression in Spinal Motor Neurons Has No Therapeutic Effect on ALS-Related Pathology in SOD1G93A Mice

    NEUROTHERAPEUTICS 20 1820-1834. .

    [doi:10.1007/s13311-023-01424-x]

  • Corral-Pujol, M; Arpa, B; Rosell-Mases, E; Egia-Mendikute, L; Mora, C; Stratmann, T; Sanchez, A; Casanovas, A; Esquerda, JE; Mauricio, D; Vives-Pi, M; Verdaguer, J

    NOD mouse dorsal root ganglia display morphological and gene expression defects before and during autoimmune diabetes development.

    Frontiers in Endocrinology 14 1176566-1176566. .

    [doi:10.3389/fendo.2023.1176566]

  • Salvany, S; Casanovas, A; Piedrafita, L; Gras, S; Caldero, J; Esquerda, JE

    Accumulation of misfolded SOD1 outlines distinct patterns of motor neuron pathology and death during disease progression in a SOD1(G93A) mouse model of amyotrophic lateral sclerosis.

    BRAIN PATHOLOGY 32 -. .

    [doi:10.1111/bpa.13078]

  • Gras S; Blasco A; Modol-Caballero, G; Tarabal O; Casanovas A; Piedrafita L; Barranco A; Das T; Rueda R; Pereira SL; Navarro X; Esquerda JE; Calderó J

    Beneficial effects of dietary supplementation with green tea catechins and cocoa flavanols on aging-related regressive changes in the mouse neuromuscular system

    Aging-US 13 18051-18093. .

    [doi:10.18632/aging.203336]

  • Gras, S; Blasco, A; Modol-Caballero, G; Tarabal, O; CASANOVAS, A; PIEDRAFITA, L; Barranco, A; Das, T; Salvany, S; Gatius, A; Pereira, SL; Navarro, X; Rueda, R; ESQUERDA, JE; CALDERO, J

    Motoneuron deafferentation and neuroinflammation in association with aging in the spinal cord of C57BL/6J mice.

    Glia 69 474-475. .

  • Salvany, S; CASANOVAS, A; PIEDRAFITA, L; Gras, S; Blasco, A; Gatius, A; Tarabal, O; Hernandez, S; CALDERO, J; ESQUERDA, JE

    Necroptosis and microglial phagocytosis of extracellular vesicles as an early mechanisms involved in the disruption of afferent synaptic terminals on spinal cord motor neurons after acute peripheral nerve injury

    Glia 69 317-318. .

  • Salvany S; Casanovas A; Piedrafita L; Tarabal O; Hernández S; Calderó J; Esquerda JE

    Microglial recruitment and mechanisms involved in the disruption of afferent synaptic terminals on spinal cord motor neurons after acute peripheral nerve injury.

    Glia 69 1216-1240. .

    [doi:10.1002/glia.23959]

  • Blasco, A; Gras, S; Mòdol-Caballero G; Tarabal, O; Casanovas, A; Piedrafita, L; Barranco, A; Das, T; Pereira, SL; Navarro, X; Rueda, R; Esquerda, JE; Caldero, J

    Motoneuron deafferentation and gliosis occur in association with neuromuscular regressive changes during ageing in mice.

    Journal of Cachexia Sarcopenia and Muscle 11 1628-1660. .

    [doi:10.1002/jcsm.12599]

  • Gatius, A; Tarabal, O; Cayuela, P; Casanovas, A; Piedrafita, L; Salvany, S; Hernandez, S; Soler, RM; Esquerda, JE; Caldero, J

    The Y172 Monoclonal Antibody Against p-c-Jun (Ser63) Is a Marker of the Postsynaptic Compartment of C-Type Cholinergic Afferent Synapses on Motoneurons

    FRONTIERS IN CELLULAR NEUROSCIENCE 13 582-582. .

    [doi:10.3389/fncel.2019.00582]

  • Salvany, S; Casanovas, A; Tarabal, O; Piedrafita, L; Hernandez, S; Santafe, M; Soto-Bernardini, MC; Caldero, J; Schwab, MH; Esquerda, JE

    Localization and dynamic changes of neuregulin-1 at C-type synaptic boutons in association with motor neuron injury and repair

    FASEB JOURNAL 33 7833-7851. .

    [doi:10.1096/fj.201802329R]

  • Cervero, C; Blasco, A; Tarabal, O; Casanovas, A; Piedrafita, L; Navarro, X; Esquerda, JE; Caldero, J

    Glial Activation and Central Synapse Loss, but Not Motoneuron Degeneration, Are Prevented by the Sigma-1 Receptor Agonist PRE-084 in the Smn(2B/-) Mouse Model of Spinal Muscular Atrophy

    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 77 577-597. .

    [doi:10.1093/jnen/nly033]

  • Casanovas, A; Salvany, S; Lahoz, V; Tarabal, O; Piedrafita, L; Sabater, R; Hernandez, S; Caldero, J; Esquerda, JE

    Neuregulin 1-ErbB module in C-bouton synapses on somatic motor neurons: molecular compartmentation and response to peripheral nerve injury

    SCIENTIFIC REPORTS 7 40155-40155. .

    [doi:10.1038/srep40155]

Projectes

  • Preclinical Analisis of new combinatorial treatments for spinal muscular atrophy (SMA): Effects on motorneuron survival, synaptic integrity, and skeletal muscle preservation.
  • El sistema NRG1-ErbBs en la arquitectura molecular de las sinapsis aferentes de tipo C y su significado en las enfermedades de la motoneurona
  • Los aferentes sinápticos de tipo C en las motoneuronas: implicaciones en la fisiopatología y terapia de la esclerosis lateral amiotrófica y de la atrofia muscular espinal (Motoneurona)
  • La esclerosis lateral amiotrófica como enfermedad proteinopática y neuroimflamatoria: estrategias de inmunoterapia (Vacunas y ELA)
  • Excitotoxicidad, plegamiento anómalo de proteinas y mecanismos inmunológicos en la esclerosis lateral amiotrófica
  • Mecanismes excitotòxics, resposta neuroinflamatòria i factors sèrics en l´esclerosi lateral amiotròfica humana i experimental