Research > Cancer

Developmental and Oncogenic Signaling

• Overview
• Strategic lines
• Publications
• Members
• Projects

DEVELOPMENTAL SIGNALING

• Mouse modelling of molecular mechanisms involved in development of genitourinary system.
• Study molecular mechanisms and biological effects of Sprouty-in tissue modelling and development.
• Study cellular senescence functions during development.
• Mouse modelling of molecular mechanisms involved in brain development.
• Study of RhoGTPases and FLT proteins in cortex development.
• Molecular mechanisms of neuron migration and axon guidance in the developing cortex and their contribution to related diseades.

ONCOGENIC SIGNALING

• Generation of mouse models of endometrial carcinogenesis.
• Identification of targeted therapies for endometrial cancer.
• Study molecular alterations downstream of PTEN deficiency in endometrial, colorectal and prostatic cancers.
• Analysis of miRNA alterations in endometrial, colorectal and prostatic cancers.
• Study of molecular-histopathological correlations in mouse models of endometrial cancer.
• Study molecular mechanisms and biological effects of Sprouty-in cancer.