During tumor progression, cancer cells adapt to changes in the microenvironment (lack of nutrients and /or oxygen) through the activation of stress pathways and autophagy. These processes are relevant in the resistance of the tumor to treatment and therefore important in the fight against cancer. Our group studies the relationship between calcium signaling and these adaptive processes, with the aim of proposing antitumoral strategies. The reason for this relationship stems from our findings that showed that T-channel deficiency activates processes of death or proliferative arrest in tumor cells. Currently our working model is Glioblastoma, an aggressive brain tumor that is characterized by its rapid growth, high invasiveness, plasticity and resistance to treatment. We use primary cultures derived from human biopsies, biochemical and cell biology techniques, gene silencing, and preclinical models of glioblastoma. The group is formed by two senior researchers, a postdoctoral researcher, a predoctoral researcher and technical staff.
Visa, A; Alza, L; Canti, C; Herreros, J
Tetralol derivative NNC-55-0396 induces glioblastoma cell death by activating IRE1a, JNK1 and calcium signaling.
BIOMEDICINE & PHARMACOTHERAPY 149 112881-112881. .
Visa, A; Sallan, MC; Maiques, O; Alza, L; Talavera, E; Lopez-Ortega, R; Santacana, M; Herrero, J; Canti, C
T-Type Ca(v)3.1 Channels Mediate Progression and Chemotherapeutic Resistance in Glioblastoma
CANCER RESEARCH 79 1857-1868. .