The group studies the cellular and molecular bases of neuromuscular disorders, particularly, motoneuron diseases such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). For this, we use in vitro and in vivo models, mainly chick embryo and transgenic mice. Several lines of work are currently underway to examine the role of excitotoxicity, autoimmunity and neuroinflammation in the ALS and SMA pathogenesis, and to identify new targets for future therapies. Another important aspect of our research is the analysis of plastic changes in central and peripheral synapses in the context of normal development, aging and motoneuron diseases.
Projects managed at the University of Lleida:
- Project: Los aferentes sinápticos de tipo C en las motoneuronas: implicaciones en la fisiopatología y terapia de la esclerosis lateral amiotrófica y de la atrofia muscular espinal, SAF2015-70801-R, National Biomedicine Program, Start date: 2016, End date: 2018.
Tapia O; Narcís JO; Riancho J; Tarabal O; Piedrafita L; Calderó J; Berciano MT; Lafarga M
Cellular bases of the RNA metabolism dysfunction in motor neurons of a murine model of spinal muscular atrophy: Role of Cajal bodies and the nucleolus
NEUROBIOLOGY OF DISEASE 108 83-99. .