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Neuronal Signalling Unit

The Neuronal Signaling Unit is a research group focused on the study of the mechanisms of degeneration of neurons in the framework of Spinal Muscular Atrophy (AME). SMA is a childhood neurodegenerative disease characterized by the loss of spinal motoneurons due to the mutation of the SMN1 gene (Survival Motor Neuron). The decrease of the SMN protein causes the degeneration of axons and the death of these neurons by mechanisms still under study.

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Gatius A.; Tarabal O.; Cayuela P.; Casanovas A.; Piedrafita L.; Salvany S.; Hernández S.; Soler R.M.; Esquerda J.E.; Calderó J.

The Y172 Monoclonal Antibody Against p-c-Jun (Ser63) Is a Marker of the Postsynaptic Compartment of C-Type Cholinergic Afferent Synapses on Motoneurons

FRONTIERS IN CELLULAR NEUROSCIENCE 13 582-582. .

[doi:10.3389/fncel.2019.00582]

García-Morales V; Rodríguez-Bey G; Gómez-Pérez L; Domínguez-Vías G; González-Forero D; Portillo F; Campos-Caro A; Gento-Caro Á; Issaoui N; Soler RM; Garcera A; Moreno-López B

Sp1-regulated expression of p11 contributes to motor neuron degeneration by membrane insertion of TASK1.

Nature Communications 10 3784-3784. .

[doi:10.1038/s41467-019-11637-4]

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Rosa Maria Soler Tatche

Rosa Maria Soler Tatche