The objectives of our research team are:
- To uncover knowledge of the as yet undiscovered etiopatological processes, of Multiple Sclerosis.
- To identify biomarkers of clinical evolution and / or response to treatment that help the physician to be able to make a treatment personalization with the ultimate goal of improving the patient's quality of life.
Our primary our focus is the study of environmental factors triggering the disease with a special interest in oxidative processes and mitochondrial function. We investigate the free radical generation and regulation by mitochondria, the detection and quantification of specific biomarkers of oxidative injury to carbohydrates, lipids, proteins and nucleic acids; targeting proteins of oxidation, the level of unsaturation of the cellular membranes, their sensitivity to lipooxidation injury, metabolic changes and cellular adaptations to oxidative stress.
Gonzalez-Mingot, C; Sanchez-Monge, IR; Purroy, F; Solana-Moga, MJ; Peralta-Moncusi, S; Lazo-Latorre, C; Gil-Villar, MP; Brieva, L
Environmental-analytical risk factors influence on the phenotype of amyotrophic lateral sclerosis in a rural setting
REVISTA DE NEUROLOGIA 65 203-208. .
Fernandez, Oscar; Oterino, Agustin; Oreja-Guevara, Celia; Prieto, Jose M.; del Mar Mendibe-Bilbao, Maria; Garcia-Merino, Juan A.; Ramio-Torrenta, Lluis; Ginestal, Ricardo; Meca-Lallana, Jose E.; Romero-Pinel, Lucia; Munoz, Delicias; Oliva-Nacarino, Pedro; Carmen Calles-Hernandez, M.; Izquierdo, Guillermo; Luisa Martinez-Gines, M.; Saiz, Albert; Comabella, Manuel; Casanova-Estruch, Bonaventura; Brieva, Lluis; Arroyo, Rafael; Rodriguez-Antiguedad, Alfredo
Review of the novelties from the 32nd ECTRIMS Congress, 2016, presented at the 9th Post-ECTRIMS Meeting (II)
REVISTA DE NEUROLOGIA 65 75-84. .