The Neuronal Signaling Unit is a research group focused on the study of the mechanisms of degeneration of neurons in the framework of Spinal Muscular Atrophy (AME). SMA is a childhood neurodegenerative disease characterized by the loss of spinal motoneurons due to the mutation of the SMN1 gene (Survival Motor Neuron). The decrease of the SMN protein causes the degeneration of axons and the death of these neurons by mechanisms still under study.
Piras A; Schiaffino L; Boido M; Valsecchi V; Guglielmotto M; De Amicis E; Puyal J; Garcera A; Tamagno E; Soler RM; Vercelli A
Inhibition of autophagy delays motoneuron degeneration and extends lifespan in a mouse model of spinal muscular atrophy.
CELL DEATH & DISEASE 8 3223-3223. .
Arumugam S; Garcera A; Soler RM; Tabares L
Smn-Deficiency Increases the Intrinsic Excitability of Motoneurons
FRONTIERS IN CELLULAR NEUROSCIENCE 11 269-269. .