The overall goal of our investigations concerned the role of metabolism and oxidative stress (including free radical chemistry, redox biology and antioxidants) in the aging process and age-associated diseases. We have investigated the role of metabolism and oxidative stress in animal models (vertebrates and invertebrates) and humans in which aging rate and longevity are different or are experimentally modified (e.g. caloric restriction, methionine restriction, and genetic manipulations) or pathologically affected (e.g. metabolic diseases, cardiovascular disease, cancer, neurodegeneratives diseases). If the aging process could be slowed or even reverted the incidence of age-related diseases would diminish significantly.
Collazo, C; Abadias, M; Colas-Meda, P; Iglesias, MB; Granado-Serrano, AB; Serrano, J; Viñas I
Effect of &ITPseudomonas graminis&IT strain CPA-7 on the ability of &ITListeria&IT &ITmonocytogene&ITs and &ITSalmonella enterica&IT subsp &ITenterica&IT to colonize Caco-2 cells after pre-incubation on fresh-cut pear
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY 262 55-62. .
Fourcade, S; Morato, L; Parameswaran, J; Ruiz, M; Ruiz-Cortes, T; Jove, M; Naudi, A; Martinez-Redondo, P; Dierssen, M; Ferrer, I; Villarroya, F; Pamplona, R; Vaquero, A; Portero-Otin, M; Pujol, A
Loss of SIRT2 leads to axonal degeneration and locomotor disability associated with redox and energy imbalance
AGING CELL 16 1404-1413. .
Reinald Pamplona Gras
Biomedicine I / Biomedicina I
3rd floor / 3ra planta