The main interest of our laboratory is the study of the molecular events underlying the oncogenic process in colorectal, gastric, head-and-neck and endometrial cancer. Gaining a deeper understanding of the molecular mechanisms responsible for the tumorigenic process is essential to improve diagnosis, but most importantly to identify novel actionable targets for patient treatment. We are also interested in the identification of predictive biomarkers and the study of drug-induced senescence to contribute to precision medicine and to the design of alternative treatment strategies for colorectal cancer patients, respectively. Finally, we explore novel therapeutic options for microvillus inclusion disease (MVID), a rare life-threatening intestinal disorder. 

Featured publications

Fourniols, T; Maggio, V; Rafael, D; Colaco, A; García Vidal E; Lopes, A; Schwartz, S; Martínez-Barriocanal, A; Preat, V; Arango, D

Colorectal cancer inhibition by BET inhibitor JQ1 is MYC-independent and not improved by nanoencapsulation.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS 171 39-49. .

[doi:10.1016/j.ejpb.2021.10.017]

Giralt, I; Gallo-Oller, G; Navarro, N; Zarzosa, P; Pons, G; Magdaleno, A; Segura, MF; Sabado, C; Hladun, R; Arango, D; Sánchez de Toledo J; Moreno, L; Gallego, S; Roma, J

Dickkopf-1 Inhibition Reactivates Wnt/ß-Catenin Signaling in Rhabdomyosarcoma, Induces Myogenic Markers In Vitro and Impairs Tumor Cell Survival In Vivo.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 22 -. .

[doi:10.3390/ijms222312921]

Martinez-Barriocanal, A; Arango, D; Dopeso, H

PVT1 Long Non-coding RNA in Gastrointestinal Cancer.

Frontiers in oncology 10 38-38. .

[doi:10.3389/fonc.2020.00038]

All publications

Responsable/s de grup

Diego Arango Del Corro

Diego Arango Del Corro

Biomedicine I / Biomedicina I
4th floor / 4a planta
Lab b4.8