The Yeast Signalling Group uses the eukaryotic model 'Saccharomyces cerevisiae’ to study the responses to oxidative stress in conjunction with cellular aging mechanisms. Specifically, our work encompasses the molecular, cellular and genetic study of both the cellular signalling pathways that mediate the previous processes and the important role that the availability of iron and associated proteins plays in cellular anti-aging and anti-oxidative stress mechanisms, such as autophagy and mitophagy. Modeling in yeast allowing us to extrapolate of our knowledge to mouse and human models.
Pujol-Carrion N; Torre-Ruiz MA
Physical interaction between the MAPK Slt2 of the PKC1-MAPK pathway and Grx3/Grx4 glutaredoxins is required for the oxidative stress response in budding yeast
FREE RADICAL BIOLOGY AND MEDICINE 103 107-120. .
Mozo-Villarías A; Cedano J; Querol E
Vector description of electric and hydrophobic interactions in protein homodimers
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS 45 341-346. .