"Precise engineering of the mammalian genome”

External Seminar
Wednesday, February 12, 2020

Marc Güell, PhD
Investigador Principal, Translational Synthetic Biology group, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (Barcelona)

Coordina: Glòria Arqué(ELIMINAR), Investigadora del grup de Neurociències Clíniques de l'IRBLleida 

Over the last decade, our capacity to engineering genomes has increased significantly impacting biomedical research and medicine. Despite important progress, mammalian genome engineering still faces important challenges such as limited multiplexability and difficulty to efficiently generate large  edits. I will present our past effort in using CRISPR/cas9 technologies to create pigs free of PERVs for xenotransplantation after tens of simultaneous edits, and new methodologies to deliver large constructs into mammalian cells in the context of gene therapy.