Directorio de personas
Manuel Portero Otin

Manuel Portero Otin

Grado: Doctor/a

973 702 408
manuel.portero(ELIMINAR)@udl.cat

ResearcherID: http://www.researcherid.com/rid/B-7122-2009

Grupos

Publicaciones

  • Pamplona, R; Portero-Otin, M; Requena, J; Gredilla, R; Barja, G

    Oxidative, glycoxidative and lipoxidative damage to rat heart mitochondrial proteins is lower after 4 months of caloric restriction than in age-matched controls.

    MECHANISMS OF AGEING AND DEVELOPMENT 123 1437-1446. .

    [doi:10.1016/S0047-6374(02)00076-3]

  • Portero-Otin, M; Pamplona, R; Bellmunt, MJ; Ruiz, MC; Prat, J; Salvayre, R; Negre-Salvayre, A

    Advanced glycation end product precursors impair epidermal growth factor receptor signaling.

    Diabetes 51 1535-1542. .

    [doi:10.2337/diabetes.51.5.1535]

  • Pamplona R; Barja G; PORTERO OTIN, MANUEL

    Membrane fatty acid unsaturation, protection against oxidative stress, and maximum life span: a homeoviscous-longevity adaptation?

    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 959 475-490. .

  • Doñate T; Herreros A; Martinez E; Martinez J; Andrés E; Cabezas A; Ortiz A; de Prado A; Pou JM; Pamplona R; Portero Otin M; Bellmunt MJ

    Protein oxidative stress in dialysis patients.

    Advances In Peritoneal Dialysis. Conference On Peritoneal Dialysis 18 15-17. .

  • Pamplona R; PORTERO OTIN, MANUEL; Bellmun MJ; Gredilla R; Barja G

    Aging increases Nepsilon-(carboxymethyl)lysine and caloric restriction decreases Nepsilon-(carboxyethyl)lysine and Nepsilon-(malondialdehyde)lysine in rat heart mitochondrial proteins.

    FREE RADICAL RESEARCH 36 47-54. .

  • Pamplona, R; Portero-Otin, M; Bellmunt, MJ; Gredilla, R; Barja, G

    Aging increases N(epsilon)-(carboxymethyl)lysine and caloric restriction decreases N(epsilon)-(carboxyethyl)lysine and N(epsilon)-(malondialdehyde)lysine in rat heart mitochondrial proteins

    FREE RADICAL RESEARCH 36 47-54. .

    [doi:10.1080/10715760290001281]

  • Portero-Otin, M; Bellmunt, MJ; Ruiz, MC; Barja, G; Pamplona, R

    Correlation of fatty acid unsaturation of the major liver mitochondrial phospholipid classes in mammals to their maximum life span potential.

    Lipids 36 491-498. .

    [doi:10.1007/s11745-001-0748-y]

  • Gredilla, R; Lopez Torres, M; Portero-Otin, M; Pamplona, R; Barja, G

    Influence of hyper- and hypothyroidism on lipid peroxidation, unsaturation of phospholipids, glutathione system and oxidative damage to nuclear and mitochondrial DNA in mice skeletal muscle.

    MOL CELL BIOCHEM 221 41-48. .

    [doi:10.1023/A:1010930110382]

  • Herrero, A; Portero-Otin, M; Bellmunt, MJ; Pamplona, R; Barja, G

    Effect of the degree of fatty acid unsaturation of rat heart mitochondria on their rates of H2O2 production and lipid and protein oxidative damage.

    MECHANISMS OF AGEING AND DEVELOPMENT 122 427-443. .

    [doi:10.1016/S0047-6374(01)00214-7]

  • Pamplona, R; Portero-Otin, M; Riba, D; Requena, JR; Thorpe, SR; Lopez-Torres, M; Barja, G

    Low fatty acid unsaturation: a mechanism for lowered lipoperoxidative modification of tissue proteins in mammalian species with long life spans.

    JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 55 286-291. .

  • Portero-Otin, M; Pamplona, R; Bellmunt, MJ; Ruiz, C; Lafarga, A; Salvayre, R; Negre-Salvayre, A

    Maillard-reaction derived oxoaldehydes inhibit epidermal-growth factor receptor activity in human cultured endothelial cells

    Diabetes 49 1395-1395. .

  • Pamplona, R; Portero-Otin, M; Ruiz, C; Gredilla, R; Herrero, A; Barja, G

    Double bond content of phospholipids and lipid peroxidation negatively correlate with maximum longevity in the heart of mammals.

    MECHANISMS OF AGEING AND DEVELOPMENT 112 169-183. .

    [doi:10.1016/S0047-6374(99)00045-7]

Proyectos

  • SEED-ALS: Synergizing Efforts to Develop and Accelerate Breakthroughs in ALS Research
  • Natural microbicides from rice against current and emerging infectious diseases
  • Humanised mouse models to study ATG4B cryptic exon involvement in ALS pathogenesis and its potential as disease biomarker (Hum4ALS)
  • Targeting cryptic exons as biomarkers and ALS therapy
  • Desregulacion de TDP-43,eje clave en la ELA: Caracterización de firmas lipidómicas, transcriptómicas y autofágicas en muestras específicas de pacientes para biomarcadores y reposicionamiento
  • Comprehensive Roadmap and Preclinical Evaluation of Antisense Oligonucleotides (ASOs) Regulatory Development and Toxicological Assessment for ALS Treatment
  • The role of defects in mitochondria-associated ER membranes (MAM) to Amyotrophic Lateral Sclerosis
  • Perspectivas clínicas de la biología de sistemas aplicada al análisis de placas carotídeas humanas: ILER-CAROTID
  • Metabolismo lipidico intracelular, procesamiento de ARNm y estrés celular en la encrucijada de la fisiopatología de la esclerosis lateral amiotrófica
  • Identification of compounds for inhibition of ACE2 membrane expression
  • Reposicionamiento terapéutico dirigido a inhibición de expresión de ACE2 y de proteolisis de trímero S viral
  • Determinació de components bioactius derivats de la microbiota mitjançant micromostreig