Directorio de personas
Manuel Portero Otin

Manuel Portero Otin

Grado: Doctor/a

973 702 408
manuel.portero(ELIMINAR)@udl.cat

ResearcherID: http://www.researcherid.com/rid/B-7122-2009

Grupos

Publicaciones

  • Muntane, G.; Dalfo, E.; Martinez, A.; Rey, M. J.; Avila, J.; Perez, M.; Portero, M.; Pamplona, R.; Ayala, V.; Ferrer, I.

    Glial fibrillary acidic protein is a major target of glycoxidative and lipoxidative damage in Pick's disease.

    JOURNAL OF NEUROCHEMISTRY 99 177-185. .

    [doi:10.1111/j.1471-4159.2006.04032.x]

  • Sanz, Alberto; Caro, Pilar; Ayala, Victoria; Portero-Otin, Manuel; Pamplona, Reinald; Barja, Gustavo

    Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins.

    FASEB JOURNAL 20 1064-1073. .

    [doi:10.1096/fj.05-5568com]

  • Sorensen, M; Sanz, A; Gomez, J; Pamplona, R; Portero-Otin, M; Gredilla, R; Barja, G

    Effects of fasting on oxidative stress in rat liver mitochondria.

    FREE RADICAL RESEARCH 40 339-347. .

    [doi:10.1080/10715760500250182]

  • Venditti, P; Pamplona, R; Portero-Otin, M; De Rosa, R; Di Meo, S

    Effect of experimental and cold exposure induced hyperthyroidism on H2O2 production and susceptibility to oxidative stress of rat liver mitochondria.

    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 447 11-22. .

    [doi:10.1016/j.abb.2006.01.008]

  • Magwere, T; Pamplona, R; Miwa, S; Martinez-Diaz, P; Portero-Otin, M; Brand, MD; Partridge, L

    Flight activity, mortality rates, and lipoxidative damage in Drosophila.

    JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 61 136-145. .

  • Nicolay, Jan P.; Schneider, Juliane; Niemoeller, Olivier M.; Artunc, Ferruh; Portero-Otin, Manuel; Haik, Jr., George; Thornalley, Paul J.; Schleicher, Erwin; Wieder, Thomas; Lang, Florian

    Stimulation of suicidal erythrocyte death by methylglyoxal

    Cellular Physiology And Biochemistry 18 223-232. .

    [doi:10.1159/000097669]

  • Pamplona, Reinald; Portero-Otin, Manuel; Sanz, Alberto; Ayala, Victoria; Vasileva, Ekaterina; Barja, Gustavo

    Protein and lipid oxidative damage and complex I content are lower in the brain of budgerigar and canaries than in mice. Relation to aging rate.

    AGE 27 267-280. .

    [doi:10.1007/s11357-005-4562-x]

  • Ruiz, MC; Ayala, V; Portero-Otin, M; Requena, JR; Barja, G; Pamplona, R

    Protein methionine content and MDA-lysine adducts are inversely related to maximum life span in the heart of mammals.

    MECHANISMS OF AGEING AND DEVELOPMENT 126 1106-1114. .

    [doi:10.1016/j.mad.2005.04.005]

  • Dalfo, E; Portero-Otin, M; Ayala, V; Martinez, A; Pamplona, R; Ferrer, I

    Evidence of oxidative stress in the neocortex in incidental Lewy body disease.

    JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 64 816-830. .

  • Dalfo, E.; Portero-Otin, M.; Ayala, V.; Pamplona, R.; Ferrer, I.

    Evidence of oxidative stress in the neocortex in incidental Lewy body disease

    MOLECULAR & CELLULAR PROTEOMICS 4 183-183. .

  • Pamplona, R; Dalfo, E; Ayala, VR; Bellmunt, MJ; Prat, J; Ferrer, I; Portero-Otin, M

    Proteins in human brain cortex are modified by oxidation, glycoxidation, and lipoxidation. Effects of Alzheimer disease and identification of lipoxidation targets.

    Journal Of Biological Chemistry 280 21522-21530. .

    [doi:10.1074/jbc.M502255200]

  • Sanz, A; Gredilla, R; Pamplona, R; Portero-Otin, M; Vara, E; Tresguerres, J; Barja, G

    Effect of insulin and growth hormone on rat heart and liver oxidative stress in control and caloric restricted animals.

    Biogerontology 6 15-26. .

    [doi:10.1007/s10522-004-7380-0]

Proyectos

  • SEED-ALS: Synergizing Efforts to Develop and Accelerate Breakthroughs in ALS Research
  • Natural microbicides from rice against current and emerging infectious diseases
  • Humanised mouse models to study ATG4B cryptic exon involvement in ALS pathogenesis and its potential as disease biomarker (Hum4ALS)
  • Targeting cryptic exons as biomarkers and ALS therapy
  • Desregulacion de TDP-43,eje clave en la ELA: Caracterización de firmas lipidómicas, transcriptómicas y autofágicas en muestras específicas de pacientes para biomarcadores y reposicionamiento
  • Comprehensive Roadmap and Preclinical Evaluation of Antisense Oligonucleotides (ASOs) Regulatory Development and Toxicological Assessment for ALS Treatment
  • The role of defects in mitochondria-associated ER membranes (MAM) to Amyotrophic Lateral Sclerosis
  • Perspectivas clínicas de la biología de sistemas aplicada al análisis de placas carotídeas humanas: ILER-CAROTID
  • Metabolismo lipidico intracelular, procesamiento de ARNm y estrés celular en la encrucijada de la fisiopatología de la esclerosis lateral amiotrófica
  • Identification of compounds for inhibition of ACE2 membrane expression
  • Reposicionamiento terapéutico dirigido a inhibición de expresión de ACE2 y de proteolisis de trímero S viral
  • Determinació de components bioactius derivats de la microbiota mitjançant micromostreig