Directorio de personas
Manuel Portero Otin

Manuel Portero Otin

Grado: Doctor/a

973 702 408
manuel.portero(ELIMINAR)@udl.cat

ResearcherID: http://www.researcherid.com/rid/B-7122-2009

Grupos

Publicaciones

  • Portero-Otin, Manuel; Pamplona, Reinald; Boada, Jordi; Jove, Mariona; Gonzalo, Hugo; Buleon, Marie; Linzc, Wolfgang; Schaefer, Stefan; Tack, Ivan; Girolami, Jean-Pierre

    Inhibition of renin angiotensin system decreases renal protein oxidative damage in diabetic rats.

    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 368 528-535. .

    [doi:10.1016/j.bbrc.2008.01.101]

  • Pamplona R; Ilieva E; Ayala V; Bellmunt MJ; Cacabelos D; Dalfo E; Ferrer I; Portero-Otin M

    Maillard reaction versus other nonenzymatic modifications in neurodegenerative processes.

    ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 1126 315-319. .

    [doi:10.1196/annals.1433.014]

  • Naudi, Alba; Caro, Pilar; Jove, Mariona; Gomez, Jose; Boada, Jordi; Ayala, Victoria; Portero-Otin, Manuel; Barja, Gustavo; Pamplona, Reinald

    Methionine restriction decreases endogenous oxidative molecular damage and increases mitochondrial biogenesis and uncoupling protein 4 in rat brain.

    REJUVENATION RESEARCH 10 473-484. .

    [doi:10.1089/rej.2007.0538]

  • Ilieva, Ekaterina V.; Ayala, VictorRia; Jove, Mariona; Dalfo, Esther; Cacabelos, Daniel; Povedano, Monica; Bellmunt, Maria Josep; Ferrer, Isidre; Pamplona, Reinald; Portero-Otin, Manuel

    Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis.

    BRAIN 130 3111-3123. .

    [doi:10.1093/brain/awm190]

  • Cantero, Anne-Valerie; Portero-Otin, Manuel; Ayala, Victoria; Auge, Nathalie; Sanson, Marie; Elbaz, Meyer; Thiers, Jean-Claude; Pamplona, Reinald; Salvayre, Robert; Negre-Salvayre, Anne

    Methylglyoxal induces advanced glycation end product (AGEs) formation and dysfunction of PDGF receptor-beta: implications for diabetic atherosclerosis.

    FASEB JOURNAL 21 3096-3106. .

    [doi:10.1096/fj.06-7536com]

  • Gomez, Jose; Caro, Pilar; Naudi, Alba; Portero-Otin, Manuel; Pamplona, Reinald; Barja, Gustavo

    Effect of 8.5% and 25% caloric restriction on mitochondrial free radical production and oxidative stress in rat liver.

    Biogerontology 8 555-566. .

    [doi:10.1007/s10522-007-9099-1]

  • Ilieva, E; Naudi, A; Dalfo, E; Ayala, V; Ferrer, I; Portero-Otin, M; Pamplona, R

    Implication of oxidative and endoplasmic reticulum stress in Pick's disease

    FREE RADICAL RESEARCH 41 33-33. .

  • Brunet, Nuria; Tarabal, Olga; Portero-Otin, Manel; Oppenheim, Ronald W.; Esquerda, Josep E.; Caldero, Jordi

    Survival and death of mature avian motoneurons in organotypic slice culture: trophic requirements for survival and different types of degeneration.

    Journal Of Comparative Neurology 501 669-690. .

    [doi:10.1002/cne.21157]

  • Ayala, Victoria; Naudi, Alba; Sanz, Alberto; Caro, Pilar; Portero-Otin, Manuel; Barja, Gustavo; Pamplona, Reinald

    Dietary protein restriction decreases oxidative protein damage, peroxidizability index, and mitochondrial complex I content in rat liver.

    JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 62 352-360. .

  • Caro, Pilar; Gomez, Jose; Sanz, Alberto; Portero-Otin, Manel; Pamplona, Reinald; Barja, Gustavo

    Effect of graded corticosterone treatment on aging-related markers of oxidative stress in rat liver mitochondria.

    Biogerontology 8 1-11. .

    [doi:10.1007/s10522-006-9026-x]

  • Muntane, G.; Dalfo, E.; Martinez, A.; Rey, M. J.; Avila, J.; Perez, M.; Portero, M.; Pamplona, R.; Ayala, V.; Ferrer, I.

    Glial fibrillary acidic protein is a major target of glycoxidative and lipoxidative damage in Pick's disease.

    JOURNAL OF NEUROCHEMISTRY 99 177-185. .

    [doi:10.1111/j.1471-4159.2006.04032.x]

  • Sanz, Alberto; Caro, Pilar; Ayala, Victoria; Portero-Otin, Manuel; Pamplona, Reinald; Barja, Gustavo

    Methionine restriction decreases mitochondrial oxygen radical generation and leak as well as oxidative damage to mitochondrial DNA and proteins.

    FASEB JOURNAL 20 1064-1073. .

    [doi:10.1096/fj.05-5568com]

Proyectos

  • SEED-ALS: Synergizing Efforts to Develop and Accelerate Breakthroughs in ALS Research
  • Natural microbicides from rice against current and emerging infectious diseases
  • Humanised mouse models to study ATG4B cryptic exon involvement in ALS pathogenesis and its potential as disease biomarker (Hum4ALS)
  • Targeting cryptic exons as biomarkers and ALS therapy
  • Desregulacion de TDP-43,eje clave en la ELA: Caracterización de firmas lipidómicas, transcriptómicas y autofágicas en muestras específicas de pacientes para biomarcadores y reposicionamiento
  • Comprehensive Roadmap and Preclinical Evaluation of Antisense Oligonucleotides (ASOs) Regulatory Development and Toxicological Assessment for ALS Treatment
  • The role of defects in mitochondria-associated ER membranes (MAM) to Amyotrophic Lateral Sclerosis
  • Perspectivas clínicas de la biología de sistemas aplicada al análisis de placas carotídeas humanas: ILER-CAROTID
  • Metabolismo lipidico intracelular, procesamiento de ARNm y estrés celular en la encrucijada de la fisiopatología de la esclerosis lateral amiotrófica
  • Identification of compounds for inhibition of ACE2 membrane expression
  • Reposicionamiento terapéutico dirigido a inhibición de expresión de ACE2 y de proteolisis de trímero S viral
  • Determinació de components bioactius derivats de la microbiota mitjançant micromostreig