Generation of gene edited pigs as model of human diseases

Tipo

External Seminar

Fecha

martes, 26 enero 21

Profesores

JOAQUIN GADEA (jgadea@um.es)

Full Professor in Physiology at the University of Murcia and IP in the Biomedical Research Institute of Murcia (IMIB).

Doctor in Veterinary Medicine (DVM, 1990) and a PhD in Animal Reproduction (1997) from the University of Murcia. Diplomate in Animal Reproduction by the European College of Animal Reproduction (2001).

My teaching activity is related to Veterinary Physiology for undergraduate students and Biology of Reproduction in MSc. Course of Biology and Technology of Reproduction and PhD programme Biology and Technology of Reproductive Health.

My research activity has been focused on the field of reproduction biology. In the las 15 years, we have been working the generation of transgenic animals that serve as experimental models taking advantage of the ability of sperm to bind and transport exogenous DNA (Sperm mediated Gene Transfer, SMGT), the use of lentiviruses and recently the use of nucleases (CRISPS-Cas9) to generate gene edited pigs that serve as models of human disease.

Abstract:

Although most of the research activity is based in the use of rodents as animal model, pigs are an excellent animal model for understanding the pathogenesis of human disease and developing therapeutic strategies.

The application of new technologies for the gene edition of pigs open a great possibility for the use of robust pig models for the study of human diseases. In this seminar we try to analyse the competitive advantages that the use of pigs could offer in the translational biomedicine research, the methodology that is used for the generation of these gene edited pig models and the possible application of these models. Finally, we will resume our experience in this field in the development of pig models for calcium signalling and neuromuscular diseases.