The group considers a genetic approach to the mechanisms that regulate the activated cell signaling pathways by proto-oncogen Ret, and its regulation by the putative tumor suppressor Sprouty. As a fundamental tool, the group uses lines of mutant mice generated by homologous recombination. The studies cover different fields such as renal development and the peripheral nervous system, or the biology of tumors of neuroendocrine origin.
Eritja N; Felip I; Dosil MA; Vigezzi L; Mirantes C; Yeramian A; Navaridas R; Santacana M; Llobet-Navas D; Yoshimura A; Nomura M; Encinas M; Matias-Guiu X; Dolcet X
A Smad3-PTEN regulatory loop controls proliferation and apoptotic responses to TGF-beta in mouse endometrium
CELL DEATH AND DIFFERENTIATION 24 1443-1458. .
Dosil MA; Mirantes C; Eritja N; Felip I; Navaridas R; Gatius S; Santacana M; Colàs E; Moiola C; Schoenenberger JA; Encinas M; Garí E; Matias-Guiu X; Dolcet X
Palbociclib has antitumour effects on Pten-deficient endometrial neoplasias
JOURNAL OF PATHOLOGY 242 152-164. .