The unit is responsible for the Pharmacology courses at the University of Lleida. The research focuses on the study of cell death processes and their modulation in order to identify new therapeutic approaches to human disease, especially cancer. The unit is structured in 2 lines of research:
- "Pharmacological modulation of cell death", directed by Prof. Boix
- "Regulation of cell death by non-coding RNA (ncRNA)", directed by Prof. Ribas
Projects managed at the University of Lleida:
- Project: Identification of molecular determinants linked to autophagy that modulates sensitivity to conventional antitumor drugs (AUTOPHAGYPHARMA), SAF2016-78657-R, National Biomedicine Program, Start date: 12/30/2016, End date: 29 / 12/2019.
- Project: Regulation of Autophagy by the TMEM49 and miR-21 genes (RAGETMEM49MIR21), SAF2011-29730, National Biomedicine Program, Start date: 01/01/2012, End date: 12/31/2014.
Mattiolo P; Yuste VJ; Boix J; Ribas J
Autophagy exacerbates caspase-dependent apoptotic cell death after short times of starvation
BIOCHEMICAL PHARMACOLOGY 98 573-586. .
Garcia-Belinchon M; Sanchez-Osuna M; Martinez-Escardo L; Granados-Colomina C; Pascual-Guiral S; Iglesias-Guimarais V; Casanelles E; Ribas J; Yuste VJ
An Early and Robust Activation of Caspases Heads Cells for a Regulated Form of Necrotic-like Cell Death
Journal Of Biological Chemistry 290 20841-20855. .