The group studies the effect of environmental stress conditions on cell proliferation in yeast Saccharomyces cerevisiae, as a model for a genetically manipulable unicellular eukaryotic organism, as well as the transduction pathways and enzymatic systems involved in the defense and repair of stress damage. Particular emphasis is placed on oxidative stress (given its biomedical implications), and on the protective role of glutaredoxin systems, which are involved in various cellular processes, since, among other functions, they participate in the formation of proteins with Fe centers -S. Defects in these co-factors cause various cellular disorders such as mitochondrial dysfunction, alterations in iron homeostasis and genomic instability, alterations associated with numerous human diseases.
Gil, Fatima N.; Belli, Gemma; Viegas, Cristina A.
The Saccharomyces cerevisiae response to stress caused by the herbicidal active substance alachlor requires the iron regulon transcription factor Aft1p
Environmental Microbiology 19 485-499. .
Pérez-Sampietro M; Serra-Cardona A; Canadell D; Casas C; Ariño J; Herrero E
The yeast Aft2 transcription factor determines selenite toxicity by controlling the low affinity phosphate transport system
SCIENTIFIC REPORTS 6 32836-32836. .